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Huperzine-A

This article is a stubmissing:
Subjective Effects
Pharmacology
Interactions
Tolerance
History & Culture
Huperzine-A molecule structureHuperzine-A molecule structure

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~50 µg
Light50-75 µg
Moderate75-150 µg

Insufflated doses are generally equivalent to oral doses. Huperzine-A is commonly administered once daily and cycled, with users typically discontinuing use after two to four weeks before resuming. The optimal dosing regimen has not been established.

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacology not written up yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Toxicity

Cardiovascular

May contribute to bradycardia (decreased heart rate), particularly when combined with other agents that slow heart rate such as beta-blockers.

Gastrointestinal

Mild cholinergic side effects including nausea, vomiting, and diarrhea may occur at typical doses.

Neuromuscular

Slight muscle twitching and slurred speech may occur as cholinergic side effects.

Secretory

Hypersalivation and sweating may occur as mild cholinergic effects.

History & Culture

History & Culture not written up yet

Legality

By Country

Not scheduled1
United States flagUnited StatesNot scheduled

References

Citations

  1. HUPERZINE A — UNII 0111871I23. precision.fda.gov (n.d.). https://precision.fda.gov/uniisearch/srs/unii/0111871i231
  2. 21 C.F.R. Part 1308—Schedules of Controlled Substances (2025 annual edition). govinfo.gov (n.d.). https://www.govinfo.gov/content/pkg/CFR-2025-title21-vol9/xml/CFR-2025-title21-vol9-part1308.xml1
  3. Controlled Substances—Alphabetical Order. deadiversion.usdoj.gov (n.d.). https://www.deadiversion.usdoj.gov/schedules/orangebook/c_cs_alpha.pdf1
  4. List I and II Regulated Chemicals—Alphabetical Order. deadiversion.usdoj.gov (n.d.). https://www.deadiversion.usdoj.gov/schedules/orangebook/f_chemlist_alpha.pdf1
  5. DEA Diversion Control Division — Controlled Substance Schedules. deadiversion.usdoj.gov (n.d.). https://www.deadiversion.usdoj.gov/schedules/schedules.html1
  6. Submitted 75-Day Premarket Notifications for New Dietary Ingredients, 1995 to Present. fda.gov (n.d.). https://www.fda.gov/media/193536/download?attachment=1
  7. 21 U.S.C. § 350b — New dietary ingredients. uscode.house.gov (n.d.). https://uscode.house.gov/view.xhtml?req=granuleid:USC-prelim-title21-section350b&num=0&edition=prelim1
  8. 21 U.S.C. § 802 — Definitions. uscode.house.gov (n.d.). https://uscode.house.gov/view.xhtml?req=granuleid:USC-prelim-title21-section802&num=0&edition=prelim1
  9. 21 U.S.C. § 813 — Treatment of controlled substance analogues. uscode.house.gov (n.d.). https://uscode.house.gov/view.xhtml?req=granuleid:USC-prelim-title21-section813&num=0&edition=prelim1

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed — this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

Times are UTCNewest first

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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