Not yet reviewed — this article is pending editorial review by Lyrea.
Citation noticeOur citation system is being overhauled
References and citation markers may currently be incomplete, mismatched, or incorrect. This system is being rebuilt and reviewed before the full site launch.
Homosildenafil
Homosildenafil is a synthetic phosphodiesterase inhibitor and an analogue of sildenafil and vardenafil, reported to produce similar effects. It was first identified in 2003 as an adulterant in sex enhancement products and has since been detected in dietary supplements and 'herbal' blends sold for sexual potency. It shows roughly 35% of sildenafil's PDE5 inhibition activity with similar selectivity. Little is known about its pharmacology or safety profile in humans.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
The drug is potentially less potent than sildenafil.
Duration
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Little is documented about the subjective experience of this compound in humans. It has been reported to produce effects similar to those of sildenafil, though its pharmacology and safety profile in humans remain largely uncharacterized.
Pharmacology
Pharmacodynamics
Homosildenafil is a synthetic phosphodiesterase inhibitor and an analog of sildenafil and vardenafil. It retains roughly 35% of the PDE5 inhibitory activity of sildenafil, with a similar selectivity profile, and is reported to produce similar effects while potentially being less potent. Little is otherwise known about its pharmacology in humans.
Pharmacokinetics
Sildenafil is metabolized mainly by the microsomal isozyme CYP3A4, with secondary metabolism by CYP2C9, and its major active metabolite is N-desmethylsildenafil. The plasma level of the equivalent homosildenafil metabolite reaches 40% of sildenafil's bioavailability. The N-desmethyl metabolite undergoes further metabolism and has a half-life of 4 hours.
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
History & Culture
Homosildenafil, also known as methyl-sildenafil, is a synthetic analog of sildenafil and vardenafil. It was first identified in 2003 as an adulterant in sex enhancement products, and has since been detected in dietary supplements.…
Legality
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed — this article is pending editorial review by Lyrea.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Recent changes7 human edits · latest
Times are UTCNewest first
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Suggest an edit
Spotted a mistake, an outdated claim, or something missing from the Homosildenafil article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.
Wish to give generalised feedback? You can do so here.