Effect Categories - Uncomfortable Bodily Effects

Uncomfortable bodily effects are defined as any uncomfortable physical effect that relates to the overall body and cannot be categorized as cardiovascular or cerebrovascular.

This page lists the various uncomfortable bodily effects that can occur under the influence of certain psychoactive compounds.


  • Back pain

    Back pain can be described as feelings of aches and pain located throughout a person's back. It is most commonly induced under the influence of heavy dosages of stimulating psychedelics compounds, such as LSD, 2C-B, and mescaline.

  • Bodily pressures

    Bodily pressures can be described as the physical experience of spontaneous pressures across different parts of the body. They are most commonly induced under the influence of heavy dosages of stimulating psychedelics, such as 2C-E, DPT, and 5-MeO-DMT.

  • Constipation

    Constipation can be described as bowel movements that are infrequent or hard to pass. It usually results in painful defecation and small, compact faeces. It is most commonly induced under the influence of heavy dosages of opioid compounds, such as heroin, tramadol, fentanyl, and kratom.

  • Dehydration

    Dehydration can be described as an uncomfortably dry mouth and feelings of general thirstiness that results due to a lack of water intake. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds such as, stimulants, psychedelics, opioids, dissociatives, deliriants, cannabinoids, alcohol, and antipsychotics.

  • Diarrhea

    Diarrhea or diarrhoea is the condition of having at least three loose or liquid bowel movements each day. It is most commonly induced under the influence of heavy dosages of certain psychedelic compounds, such as ayahuasca, mescaline, and psilocybin mushrooms.

  • Difficulty urinating

    Difficulty urinating (also known as urinary retention) can be described as the experience of a decreased ability to pass urine. It is most commonly induced under the influence of heavy dosages of stimulant and opioid compounds, such as heroin, fentanyl, kratom, amphetamine, MDMA, and 4-FA.

  • Dry mouth

    Dry mouth can be described as having a dry-feeling mouth often accompanied by a difficulty swallowing. It is usually a direct result of dehydration but can be felt to occur regardless of the actual dryness of a person's mouth. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds, such as stimulants, psychedelics, opioids, antispychotics, deliriants, SSRI's, and cannabinoids.

  • Frequent urination

    Frequent urination, or urinary frequency, can be defined as the need to urinate more often than usual. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds, such as stimulants, psychedelics, dissociatives, and deliriants.

  • Increased perspiration

    Increased perspiration, or hyperhidrosis, can be described as a condition characterized by increased sweat which is in excess of that required for the regulation of body temperature. It is most commonly induced under the influence of stimulants, psychedelics, and benzodiapine or alcohol withdrawals.

  • Increased phlegm production

    Increased phlegm production can be described as the experience of the throat and respiratory system producing excessive amounts of mucous fluid that is often expelled via coughing. It is most commonly induced under the influence of heavy dosages of tryptamine psychedelic compounds, such as psilocybin, 5-MeO-MiPT, 4-AcO-DMT, and 4-HO-MET.

  • Increased salivation

    Increased salivation can be described as the production and excretion of excess saliva within the mouth, which may also be caused by decreased clearance of saliva. It is most commonly induced under the influence of heavy dosages of psychedelic tryptamine compounds, such as psilocybin, 4-AcO-DMT, and 4-HO-MET.

  • Itchiness

    Itchiness is the sensation that causes a person the desire or reflex to scratch at their skin. It is most commonly induced under the influence of heavy dosages of opioid compounds, such as heroin, fentanyl, tramadol, and kratom.

  • Muscle cramp

    A muscle cramp can be described as an involuntary temporary contraction or over shortening of muscles which may cause severe aches and pains. They are most commonly induced under the influence of heavy dosages of stimulating psychedelic compounds, such as LSD, 2C-E, DOC, and AMT. However, they can also occur under the influence of certain GABAergic depressants such as GHB and phenibut.

  • Muscle tension

    Muscle tension can be described as extended partial contractions or over shortening of muscles which can cause persistent low-level aches and pains. It is most commonly induced under the influence of heavy dosages of stimulating psychedelic compounds, such as LSD, 2C-E, DOC, and AMT.

  • Muscle twitching

    Muscle twitching can be described as the sensation of small and localised tremblings of muscle groups. These vibrations are often powerful enough to be visibly seen through the skin. It is most commonly induced under the influence of moderate dosages of stimulating psychedelic compounds such as LSD, 2C-E, DOC, and AMT.

  • Nausea

    Nausea can be described as a sensation of unease and discomfort in the upper stomach combined with an involuntary urge to vomit. It is most commonly induced under the influence of heavy dosages of a wide variety of compounds, such as psychedelics, opioids, GABAergics, deliriants, dissociatives, and stimulants.

  • Optical sliding

    Optical sliding can be described as a physical effect which inhibits the coordination and control of a person's eyes by suppressing their ability to keep them still. It is most commonly induced under the influence of heavy dosages of dissociative compounds, such as ketamine, PCP, and DXM.

  • Photophobia

    Photophobia can be described as an abnormal physical intolerance to the visual perception of light. It is most commonly induced under the influence of heavy dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.

  • Physical fatigue

    Physical fatigue can be described as a general feeling of bodily exhaustion. It is most commonly induced under the influence of moderate dosages of antipsychotic compounds, such as quetiapine, haloperidol, and risperidone. However, it can also occur during the withdrawal symptoms of many depressants, and during the offset of many stimulants.

  • Respiratory depression

    Respiratory depression can be described as a reduced urge to breathe that can be fatal depending on its intensity. It is most commonly induced under the influence of heavy dosages of depressant compounds, particularly opioids, such as heroin and fentanyl, or GABAergics, such as alcohol and GHB. However, it is worth noting that otherwise safe dosages of these compounds can become fatal when combined with even small amounts of other classes of depressant.

  • Restless legs

    Restless legs (also known as restless legs syndrome or RLS) is a neurological disorder characterized by an irresistible urge to move one's body to stop uncomfortable or odd sensations. Restless legs syndrome is most commonly induced during the withdrawal symptoms of many depressants, such as opioids or benzodiazepines, and during the offset of many stimulants, such as methamphetamine, cocaine, and MDMA. However, it can also occur under the influence of deliriants such as DPH and datura.

  • Runny nose

    A runny nose can be described as a condition where the nasal cavity is filled with a significant amount of mucous fluid, otherwise known as "snot". It is most commonly induced under the influence of heavy dosages of tryptamine psychedelic compounds, such as psilocybin, 4-AcO-DMT, and 4-HO-MET. However, it can also occur under the influence of opioid withdrawals) and as a symptom of cocaine abuse.

  • Skin flushing

    Skin flushing can be described as the experience of a sudden reddening of the skin which is usually accompanied by feelings of rushing blood and warm skin. It is most commonly induced under the influence of heavy dosages of opioid compounds, such as heroin, tramadol, fentanyl, and kratom. However, it can also occur under the influence of alcohol, certain psychedelics such as 5-MeO-DMT, and stimulants, such as caffeine.

  • Stomach bloating

    Stomach bloating can be described as an uncomfortable physical side effect which results in one's stomach becoming temporarily bloated and expanded in a manner which looks somewhat similar to pregnancy. It is most commonly induced under the influence of heavy dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline. However, it can also occur under the influence of stimulants, opioids, and depressants.

  • Stomach cramp

    A stomach cramp can be described as an intense feeling of sudden pain or discomfort which occurs within the stomach. They are most commonly induced under the influence of heavy dosages of a wide variety of compounds, such as psychedelics, opioids, GABAergics, and deliriants.

  • Teeth chattering

    Teeth chattering is the experience of a compulsive and often uncontrollably rapid slight opening and closing of a person's mouth, similar to that of when a person is cold or afraid. It is most commonly induced under the influence of heavy dosages of serotonergic compounds, such as MDMA and DXM.

  • Teeth grinding

    Teeth grinding (also known as bruxism, jaw clenching, and gurning) can be described as a compulsive and often uncontrollable urge to grind one's teeth. It is most commonly induced under the influence of common dosages of stimulant compounds, such as methamphetamine, MDMA, methylphenidate, and cocaine. However, it can also occur under the influence of certain stimulating psychedelics such as 2C-E, DOC, and AMT.

  • Temporary erectile dysfunction

    Temporary erectile dysfunction can be described as a difficulty in achieving and maintaining an adequately erect penis for the purpose of sexual intercourse. It is most commonly induced under the influence of heavy dosages of stimulating compounds, such as traditional stimulants and certain psychedelics. However, it can also occur under the influence of opioids, dissociatives, GABAergics, and deliriants.

  • Vibrating vision

    Vibrating vision, also known as nystagmus, is the experience of constant, rapid involuntary eye movements in which the eyes shift from left to right in such quick succession that the person's vision begins to vibrate and blur. It is most commonly induced under the influence of heavy dosages of stimulant compounds, such as MDMA, amphetamine, and 4-FA.

  • Watery eyes

    Watery eyes can be described as a physical effect which results in a state of continuous involuntary streaming, tearing, crying, and watering of the tear ducts within one's eyes. It is most commonly induced under the influence of moderate dosages of psychedelic tryptamine compounds, such as psilocybin, 4-AcO-DMT, and 4-HO-MET.