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5-MeO-MET

5-MeO-MET molecule structure5-MeO-MET molecule structure
This article is a stubmissing:
Subjective Effects
Interactions
Tolerance
Legality
Chemical Class
Tryptamine

5-MeO-MET is a 5-MeO-DMT analog investigated for its in vitro receptor pharmacology and psychedelic-like effects in the mouse head-twitch response model1. Structurally, it is similar to 5-MeO-DMT and related to methylethyltryptamine (MET); its effects are likely similar to those of other psychedelic tryptamines. It is suspected to have been first synthesized by Alexander Shulgin.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~13 mg
Light13-15 mg
Moderate15-25 mg
Strong25+ mg

Duration

After Effects1-2 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

5-MeO-MET is a potent serotonin 5-HT1A receptor ligand and a serotonin 5-HT2A receptor agonist.1 After 5-HT1A antagonist pretreatment, 5-MeO-MET showed latent head-twitch activity in mice, with potency similar to 5-MeO-DMT.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Toxicity

thermoregulatory/autonomic

Sweating and chills are listed among negative effects.

musculoskeletal

Muscle tension is listed among negative effects.

central nervous system

Confusion and insomnia are listed among negative effects.

History & Culture

5-MeO-MET was first synthesized and studied to a limited extent during the 1960s. It was first identified on the illicit market in Sweden in June 2012 and was made illegal in Norway in 2013. The compound was not included or mentioned in Alexander Shulgin's book TiHKAL, which also did not describe its properties, dose, duration, or effects.

Legality

Legality not written up yet

References

Citations

  1. Serotonin 1A receptors modulate serotonin 2A receptor-mediated behavioral effects of 5-methoxy-N,N-dimethyltryptamine analogs in mice. ACS Chemical Neuroscience (2024). https://doi.org/10.1021/acschemneuro.4c005131234

Article Status

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