4-PrO-DMT
Contents
Dosage & Duration
Subjective Effects
Effects vary widely by individual, dose, and context.
Physical
The physical effects of 4-PrO-DMT can be broken down into several components all of which progressively intensify proportional to dosage. These are described below and generally include:
Cognitive
The cognitive effects of 4-PrO-DMT are described by many as extremely relaxing, profound and stoning in style when compared to other commonly used psychedelics such as LSD or 2C-B which tend to be energetic and stimulating. It contains a large number of psychedelic typical and unique cognitive effects. The most prominent of these typical effects generally include:
Visual
Distortions
As for visual distortions and alterations, the effects experienced are detailed below:
Enhancements
4-PrO-DMT presents a full and complete array of possible visual enhancements which generally includes:
Geometry
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT, Ayahuasca and 2C-E than LSD or 2C-B. It can be comprehensively described through its variations as intricate in complexity, abstract in form, organic in feel, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, soft in its edges, large in size, slow in speed, smooth in motion, rounded in its corners, non-immersive in depth and consistent in intensity. They have a very "natural" feel to them and at higher dosages are significantly more likely to result in states of Level 8B visual geometry over Level 8A.
Hallucinatory States
4-PrO-DMT and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:
Auditory
The auditory effects of 4-PrO-DMT are common in their occurrence and exhibit a full range of effects which commonly includes:
by Josie KinsApril 2015.Reagent Testing
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Pharmacology
Tolerance
Harm Potential
Addiction & Dependence
Psychological
Extremely Low4-PrO-DMT has structural and pharmacological similarities to psilacetin, a compound not associated with compulsive patterns of use.
Physical
Extremely Low4-PrO-DMT resembles psilacetin in both structure and pharmacological profile, and psilacetin is not linked with physical dependence.
Toxicity
Toxicity data for 4-PrO-DMT remain very limited. No deaths involving 4-PrO-DMT have been reported to date.
History & Culture
Trip Reports
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Legality
References
Source Pages
Further Reading
ACS Pharm.& Transl. Sci. – receptor-binding & mouse data
ACS Pharmacology & Translational Science - Receptor Binding Profiles
CaaMTech - Foundational Science for 4-PrO-DMT
EMCDDA: Early Warning Report 2020
J. Med. Chem. – novel psilocin pro-drug series- Journal of Medicinal Chemistry - Novel Psilocin Prodrugs
- PubMed: Head-Twitch Response Study
Reddit: r/microdosing – micro-dose experiences- Reddit: r/researchchemicals – psilocin pro-drug discussion
ResearchGate: psilocin HTR dose-response
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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