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4-PrO-DMT

This article is a stubmissing:
Dosage & Duration
Pharmacology
Interactions
Tolerance
History & Culture
Legality
4-PrO-DMT molecule structure4-PrO-DMT molecule structure
4-Propionyloxy-N,N-dimethyltryptamine
O-propionylpsilocin, Psilacetin propanoate ester analogue
Psychoactive Class
Psychedelic
Chemical Class
Tryptamine

Dosage & Duration

Dosage & Duration not written up yet

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Effects vary widely by individual, dose, and context.

Physical

The physical effects of 4-PrO-DMT can be broken down into several components all of which progressively intensify proportional to dosage. These are described below and generally include:

Runny noseExcessive yawningWatery eyesNauseaChanges in gravitySalivationPupil dilation

Cognitive

The cognitive effects of 4-PrO-DMT are described by many as extremely relaxing, profound and stoning in style when compared to other commonly used psychedelics such as LSD or 2C-B which tend to be energetic and stimulating. It contains a large number of psychedelic typical and unique cognitive effects. The most prominent of these typical effects generally include:

Current mind state enhancementThought connectivityNovelty enhancementTime distortionDéjà vuPersonal bias suppressionFeelings of predeterminismImmersion enhancementConceptual thinkingDirect communication with the subconsciousMemory suppressionFeelings of interdependent oppositesDelusionsUnity and interconnectednessFeelings of self-designExposure to inner mechanics of consciousnessSpirituality enhancement

Visual

Distortions

As for visual distortions and alterations, the effects experienced are detailed below:

Enhancements

4-PrO-DMT presents a full and complete array of possible visual enhancements which generally includes:

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT, Ayahuasca and 2C-E than LSD or 2C-B. It can be comprehensively described through its variations as intricate in complexity, abstract in form, organic in feel, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, soft in its edges, large in size, slow in speed, smooth in motion, rounded in its corners, non-immersive in depth and consistent in intensity. They have a very "natural" feel to them and at higher dosages are significantly more likely to result in states of Level 8B visual geometry over Level 8A.

Hallucinatory States

4-PrO-DMT and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:

Transformations

Auditory

The auditory effects of 4-PrO-DMT are common in their occurrence and exhibit a full range of effects which commonly includes:

EnhancementsDistortionsHallucinations
Adapted from the Psilocin subjective effects documentation. 4-PrO-DMT is the propionylated prodrug of psilocin (4-HO-DMT) and is reported to produce an effectively identical experience. Forked from Subjective Effect Documentation work byJosie Kins April 2015.

See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)

Pharmacology

Pharmacology not written up yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

4-PrO-DMT has structural and pharmacological similarities to psilacetin, a compound not associated with compulsive patterns of use.

Physical

Extremely Low

4-PrO-DMT resembles psilacetin in both structure and pharmacological profile, and psilacetin is not linked with physical dependence.

Toxicity

Lethal Dosage

Toxicity data for 4-PrO-DMT remain very limited. No deaths involving 4-PrO-DMT have been reported to date.

History & Culture

History & Culture not written up yet

Trip Reports

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Legality

Legality not written up yet

References

Source Pages

  1. Bluelight: 25mg oral experience report
  2. Bluelight: legal-concerns thread on 4-PrO-DMT
  3. Erowid: 4-PrO-DMT Experience Reports
  4. Wikipedia

Further Reading

  1. ACS Pharm.& Transl. Sci. – receptor-binding & mouse data
  2. ACS Pharmacology & Translational Science - Receptor Binding Profiles
  3. CaaMTech - Foundational Science for 4-PrO-DMT
  4. EMCDDA: Early Warning Report 2020
  5. J. Med. Chem. – novel psilocin pro-drug series
  6. Journal of Medicinal Chemistry - Novel Psilocin Prodrugs
  7. PubMed: Head-Twitch Response Study
  8. Reddit: r/microdosing – micro-dose experiences
  9. Reddit: r/researchchemicals – psilocin pro-drug discussion
  10. ResearchGate: psilocin HTR dose-response

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed — this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

Times are UTCNewest first

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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