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4-MeO-MiPT

4-MeO-MiPT molecule structure4-MeO-MiPT molecule structure
This article is a stubmissing:
Subjective Effects
Interactions
Tolerance
Harm Potential
Legality
4-Methoxy-N-methyl-N-isopropyltryptamine
Psychoactive Class
PsychedelicHallucinogen
Chemical Class
Tryptamine

4-MeO-MiPT is a tryptamine with psychedelic effects in humans1 and member of the 4-methoxytryptamine family. First described in 1985 by David Repke, Alexander Shulgin, and colleagues, it is the 4-methoxy analogue of MiPT and an O-methyl ether of 4-HO-MiPT. Reports characterize it as relatively mild,2 with little or no visual effects reported after oral use,2 and describe it as a “little brother” of 5-MeO-MiPT.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~10 mg
Light10 mg
Moderate10-20 mg
Strong20+ mg

Duration

Onset20-60 minutes
After Effects1-4 hours
Total3-7 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

4-MeO-MiPT inhibits the serotonin transporter, increasing extracellular serotonin, and acts as a non-selective serotonin receptor agonist. It shows agonist activity at the 5-HT1A and 5-HT2A1 and, in a G-protein assay, 5-HT2C1 receptors. In rodents, it induces the head-twitch response1, a behavioral proxy of psychedelic activity.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Harm Potential not written up yet

History & Culture

4-MeO-MiPT was first described in the scientific literature by David Repke, Alexander Shulgin, and colleagues in 1985. Alexander Shulgin later described it in greater detail as entry #39 in his 1997 book TiHKAL. A 2016 study analyzed 4-MeO-MiPT among new synthetic tryptamines purchased from an Internet shop3.

Legality

Legality not written up yet

References

Source Pages

  1. Bluelight: 4-MeO-MiPT Thread
  2. Bluelight: user reports summarised in 4-MeO-MiPT thread
  3. Erowid: 4-MeO-MiPT Vault – Dose & Experience Reports
  4. Isomer Design (TiHKAL/PiHKAL)
  5. Shulgin & Repke – TiHKAL #39: 4-MeO-MiPT
  6. Shulgin & Repke – TiHKAL #39: 4-MeO-MiPT
  7. Wikipedia

Citations

  1. Serotonin Transporter Blockade Reduces the Psychedelic-Like Effects of 4-Methoxy-N-methyl-N-isopropyltryptamine and Related Analogs. ACS Chemical Neuroscience (2026). https://doi.org/10.1021/acschemneuro.6c000831234
  2. TIHKAL #39: 4-MEO-MIPT. Erowid Online Books (2015). https://erowid.org/library/books_online/tihkal/tihkal39.shtml12
  3. Test purchase of new synthetic tryptamines via the Internet: Identity check by GC-MS and separation by HPLC. Journal of Applied Pharmaceutical Science (2016). https://doi.org/10.7324/japs.2016.6001051

Further Reading

  1. Halberstadt et al., 2025 – Pharmacological profiles of 4-HO-, 4-AcO-, and 4-MeO-MiPT
  2. Rick Strassman et al. – Human Psychopharmacology of New Tryptamines (review)

Article Status

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