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4-HO-DPT
4-HO-DPT is a synthetic psychedelic substance in the tryptamine class.1 It is a structural analogue of psilocin2. David Repke and colleagues first described it in the scientific literature in 1977.3 It is used recreationally and for entheogenic purposes, but remains relatively uncommon among substituted tryptamines because of the difficulty of its synthesis.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Pharmacology
Pharmacodynamics
4-HO-DPT acts as a serotonin receptor agonist4, with high-efficacy partial to full agonist activity at 5-HT2A, 5-HT2B, and 5-HT2C receptors.4 Its agonist potency at 5-HT2A and 5-HT2B is more than 100-fold greater than at 5-HT2C, indicating preferential activation of the former two receptors. In rodents, it induces the head-twitch response4, a behavioral proxy for psychedelic activity.4
Pharmacokinetics
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
All psychedelics
Harm Potential
Addiction & Dependence
Psychological
Higher doses may increase adverse effects, including possible addiction-related concerns, but 4-HO-DPT-specific addiction risk has not been characterized.
Toxicity
Nausea is listed among physical effects.
Psychosis Risk
Psychosis risk is specifically warned for lithium combinations and may be increased by cannabis or stimulant combinations; delusion is also listed as a cognitive effect.
Seizure Risk
Lithium is warned to significantly increase psychosis and seizure risk, and tramadol may lower the seizure threshold enough for psychedelics to trigger seizures in susceptible people.
History & Culture
Repke and colleagues first reported the synthesis of 4-HO-DPT in 1977.5 TiHKAL includes a detailed entry on 4-HO-DPT.6 In 2019, Chadeayne and colleagues determined the crystal structure of its fumarate…
Legality
International
Most jurisdictions are described as having no schedule listed for 4-HO-DPT.
By Country
References
Citations
Article Status
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