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4-HO-DPT

4-HO-DPT molecule structure4-HO-DPT molecule structure
Chemical Class

4-HO-DPT is a synthetic psychedelic substance in the tryptamine class.1 It is a structural analogue of psilocin2. David Repke and colleagues first described it in the scientific literature in 1977.3 It is used recreationally and for entheogenic purposes, but remains relatively uncommon among substituted tryptamines because of the difficulty of its synthesis.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold20 mg
Light25-50 mg
Moderate50-75 mg
Strong75-100 mg
Heavy100 mg

Duration

Onset45-60 minutes
Come Up60-120 minutes
Peak2-3 hours
Offset1-2 hours
Total5-8 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Ehrlich(EH)
white → purple1 → black2
Morr(MO)
pink2 → green1
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Pharmacology

Pharmacodynamics

4-HO-DPT acts as a serotonin receptor agonist4, with high-efficacy partial to full agonist activity at 5-HT2A, 5-HT2B, and 5-HT2C receptors.4 Its agonist potency at 5-HT2A and 5-HT2B is more than 100-fold greater than at 5-HT2C, indicating preferential activation of the former two receptors. In rodents, it induces the head-twitch response4, a behavioral proxy for psychedelic activity.4

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Tolerance to the effects of 4-HO-DPT develops almost immediately following a dose.
Baseline Reset
Tolerance returns to baseline after approximately 7 days without further use.
Half Tolerance
Tolerance decreases to approximately 50% after 3 days without further use.
Cross Tolerance

All psychedelics

Harm Potential

Addiction & Dependence

Psychological

Higher doses may increase adverse effects, including possible addiction-related concerns, but 4-HO-DPT-specific addiction risk has not been characterized.

Toxicity

gastrointestinal

Nausea is listed among physical effects.

Psychosis Risk

Psychosis risk is specifically warned for lithium combinations and may be increased by cannabis or stimulant combinations; delusion is also listed as a cognitive effect.

Seizure Risk

Lithium is warned to significantly increase psychosis and seizure risk, and tramadol may lower the seizure threshold enough for psychedelics to trigger seizures in susceptible people.

History & Culture

Repke and colleagues first reported the synthesis of 4-HO-DPT in 1977.5 TiHKAL includes a detailed entry on 4-HO-DPT.6 In 2019, Chadeayne and colleagues determined the crystal structure of its fumarate…

Legality

IllegalNothing on file

International

Most jurisdictions are described as having no schedule listed for 4-HO-DPT.

By Country

Illegal5
United States flagUnited StatesIllegal (analog/blanket ban)
Germany flagGermanyIllegal (analog/blanket ban)
Sweden flagSwedenIllegal
Switzerland flagSwitzerlandIllegal
United Kingdom flagUnited KingdomIllegal

References

Citations

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

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    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

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