4-AcO-MET
4-AcO-MET is a novel psychedelic substance of the tryptamine class and the acetate ester of 4-HO-MET, for which it is theorized to serve as a prodrug. Structurally related to 4-AcO-DMT and other acetylated tryptamines, it produces psilocybin-like psychedelic effects. It has very little history of human use, and data regarding its pharmacology, metabolism, and toxicity remain limited. It is primarily available as a research chemical through online vendors.
Contents
Dosage & Duration
Dosage
Duration
Subjective Effects
Effects vary widely by individual, dose, and context.
Physical
The physical effects of 4-AcO-MET can be broken down into three components all of which progressively intensify proportional to dosage.
Cognitive
The cognitive effects of 4-AcO-MET are described by many as somewhat relaxing, yet fast-paced in style with similarities to psychedelics such as LSD or 2C-B which tend to be cognitively energetic and stimulating.
Visual
Geometry
The visual geometry that is present throughout this trip can be described as somewhat similar in appearance to that of Psilocin, 4-AcO-DMT and 4-HO-MiPT but with far stronger synthetic digital undertones reminiscent of LSD or 2C-B. 4-AcO-MET can be comprehensively described through its variations as intricate in complexity, abstract in form, equally synthetic and organic in style, structured in organization, extremely brightly lit and multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in corners, unimmersive in depth and consistent in intensity. The visuals have a contradictory 'natural' and 'synthetic' feel to them which is reminiscent of both LSD and Psilocybin. Higher dosages are significantly more likely to result in states of Level 8A visual geometry over Level 8B.
Hallucinatory States
4-AcO-MET and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics.
Auditory
The auditory effects of 4-AcO-MET are common in their occurrence and exhibit a full range of effects.
Reagent Testing
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Pharmacology
Pharmacodynamics
The psychedelic effects of 4-AcO-MET are believed to stem from its activity at the 5-HT2A receptor, where it is thought to act as a partial agonist. 4-AcO-MET is the acetate ester of 4-HO-MET, and it is theorized to function as a prodrug that is converted to 4-HO-MET in the body, which would then mediate much of the pharmacological activity. Very little data exists about the detailed pharmacological properties of this substance, and the precise mechanisms by which its receptor interactions produce psychedelic effects remain unclear.
Pharmacokinetics
4-AcO-MET is hypothesized to be rapidly hydrolyzed into 4-HO-MET by serum esterases, in a manner analogous to how 4-AcO-DMT is thought to be deacetylated to psilocin (4-HO-DMT) during first-pass metabolism and subsequent hepatic processing. However, human studies confirming the metabolic fate of 4-AcO-MET are currently lacking.
Tolerance
Psychedelics (all serotonergic psychedelics will have reduced effects following 4-AcO-MET consumption)
Harm Potential
Addiction & Dependence
Psychological
Extremely Low4-AcO-MET is not regarded as habit-forming; with repeated use, the urge to take it may decline rather than build. Most users describe its use as self-limiting.
Physical
Extremely Low4-AcO-MET does not appear to produce physical dependence, with no documented withdrawal symptoms.
Psychosis Risk
Delusions are listed among possible cognitive effects during the acute experience. No specific data on psychosis incidence exists for this compound; standard psychedelic cautions apply regarding individuals with personal or family history of psychotic disorders.
Seizure Risk
No specific data on seizure risk exists for 4-AcO-MET.
History & Culture
4-AcO-MET, also known as metacetin, is a novel synthetic tryptamine that emerged primarily through the online research chemical market. As an acetate ester of 4-HO-MET and a structural homologue of 4-AcO-DMT, it represents one of many acetylated tryptamine derivatives that have been synthesized and…
Trip Reports
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Legality
By Country
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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