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3-MEC

3-MEC molecule structure3-MEC molecule structure
3-Methylethcathinone
3-MeEC
Psychoactive Class
Chemical Class

3-MEC is a synthetic stimulant and entactogen of the substituted cathinone class. It is a research chemical with very limited documentation, as few user reports exist in the public domain. 3-MEC is generally regarded as less potent than its positional isomer 4-MEC and is considered unpopular relative to other available cathinones. As with other research chemicals in this class, it carries a risk of habit formation.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~25 mg
Light25-50 mg
Moderate50-100 mg
Strong100-150 mg
Heavy150+ mg

Duration

Onset5-15 minutes
After Effects1-3 hours
Total1-1.5 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Mecke(ME)
white → yellow1
Mandelin(MD)
yellow2 → green2
Liebermann(LB)
white → orange2
Ehrlich(EH)
white → yellow2
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Pharmacology

Pharmacokinetics

An in-vitro metabolism study of the three methylethcathinone positional isomers tentatively identified seven metabolites for 3-MEC by liquid chromatography–high-resolution tandem mass spectrometry. The authors described this as the first report of 3-MEC metabolism.1 These are tentative structures formed in an in-vitro model; they do not establish a human metabolite profile, relative pathway contributions, bioavailability, clearance, or elimination half-life.1

Metabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Cross Tolerance

Stimulants acting on dopamine and norepinephrine systems, Other substituted cathinones

Harm Potential

Addiction & Dependence

Psychological

Classified as habit-forming.

History & Culture

3-MEC (3-Methylethcathinone) is a synthetic cathinonecitation needed that has received limited documentation in both scientific literature and user communities.

Forensic emergence

A validated liquid-chromatography tandem-mass-spectrometry method was applied to forensic serum samples collected from June 2014 through August 2016. Eight samples showed recent MMC or MEC use; after three MMC findings, the remaining five were positive for 3-MEC, while 2-MEC and 4-MEC were not

Legality

International

3-MEC is not listed by its common name, chemical names, or CAS number in the current INCB Yellow, Green, or Red Lists. It is therefore not scheduled under the 1961 Single Convention, the 1971 Convention on Psychotropic Substances, or Tables I and II of the 1988 Convention as of the cited editions; international schedules do not apply national analogue or blanket-control rules.

By Country

Illegal29
United States flagUnited StatesIllegal
Argentina flagArgentinaIllegal
Australia flagAustraliaIllegal (analog/blanket ban)
Austria flagAustriaIllegal (analog/blanket ban)
Belgium flagBelgiumIllegal (analog/blanket ban)
Brazil flagBrazilIllegal (analog/blanket ban)
Canada flagCanadaIllegal (analog/blanket ban)
Chile flagChileIllegal (analog/blanket ban)
Czech Republic flagCzech RepublicIllegal
Denmark flagDenmarkIllegal
France flagFranceIllegal (analog/blanket ban)
Germany flagGermanyIllegal (analog/blanket ban)
Ireland flagIrelandIllegal (analog/blanket ban)
Israel flagIsraelIllegal (analog/blanket ban)
Italy flagItalyIllegal (analog/blanket ban)
Japan flagJapanIllegal (analog/blanket ban)
Netherlands flagNetherlandsIllegal (analog/blanket ban)
Norway flagNorwayIllegal
Poland flagPolandIllegal (analog/blanket ban)
Portugal flagPortugalIllegal (analog/blanket ban)
Russia flagRussiaIllegal (analog/blanket ban)
Singapore flagSingaporeIllegal (analog/blanket ban)
South Africa flagSouth AfricaIllegal (analog/blanket ban)
South Korea flagSouth KoreaIllegal (analog/blanket ban)
Sweden flagSwedenIllegal
Switzerland flagSwitzerlandIllegal (analog/blanket ban)
Turkey flagTurkeyIllegal (analog/blanket ban)
Ukraine flagUkraineIllegal (analog/blanket ban)
United Kingdom flagUnited KingdomIllegal
Controlled / restricted1
Finland flagFinlandRestricted

References

Source Pages

  1. TripSit Factsheet: General cathinone information
  2. TripSit: 3-MEC Fact Sheet
  3. User experience compilation - Bluelight cathinone discussions
  4. User experience compilation – 3-MEC Megathread. Bluelight.org (Accessed 2023-08-01)

Citations

  1. Electron activated dissociation—a complementary fragmentation technique to collision-induced dissociation for metabolite identification of synthetic cathinone positional isomers. pubmed.ncbi.nlm.nih.gov (n.d.). https://doi.org/10.1016/j.aca.2023.341962123
  2. Separation of ortho, meta and para isomers of methylmethcathinone (MMC) and methylethcathinone (MEC) using LC-ESI-MS/MS: Application to forensic serum samples. pubmed.ncbi.nlm.nih.gov (n.d.). https://doi.org/10.1016/j.jchromb.2017.01.0461
  3. Decreto 560/2019, artículo 2 y Anexo I (sustituido por Decreto 122/2026); Ley 23.737, artículos 5 y 14. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/decreto-560-2019-326675/actualizacion1
  4. Decreto 560/2019, artículo 2 y Anexo I (sustituido por Decreto 122/2026); Ley 23.737, artículos 5 y 14. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/423520_dec122_jpg/archivo1
  5. Decreto 560/2019, artículo 2 y Anexo I (sustituido por Decreto 122/2026); Ley 23.737, artículos 5 y 14. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/decreto-122-2026-423520/texto1
  6. Decreto 560/2019, artículo 2 y Anexo I (sustituido por Decreto 122/2026); Ley 23.737, artículos 5 y 14. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/ley-23737-138/actualizacion1
  7. Criminal Code Act 1995, ss 301.1 and 301.9; Criminal Code Regulations 2019, Schedule 1. legislation.gov.au (n.d.). https://www.legislation.gov.au/C2004A04868/2026-06-30/2026-06-30/text/original/epub/OEBPS/document_2/document_2.html1
  8. Criminal Code Act 1995, ss 301.1 and 301.9; Criminal Code Regulations 2019, Schedule 1. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2019L00561/2025-03-01/2025-03-01/text/original/epub/OEBPS/document_1/document_1.html1
  9. Neue-Psychoaktive-Substanzen-Verordnung, Annex II, item 3, and Neue-Psychoaktive-Substanzen-Gesetz, section 4. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/geltendefassung/bundesnormen/20007642/npsv%2C%20fassung%20vom%2028.07.2021.pdf1
  10. Neue-Psychoaktive-Substanzen-Verordnung, Annex II, item 3, and Neue-Psychoaktive-Substanzen-Gesetz, section 4. ris.bka.gv.at (n.d.). https://ris.bka.gv.at/Dokumente/Bundesnormen/NOR40134447/NOR40134447.pdf1

Further Reading

  1. Baumann MH et al. - 'Second-Generation' Mephedrone Analogs, 4-MEC and 4-MePPP
  2. Cawrse BM et al. - Identifying cathinone derivatives in seized samples
  3. ChemSpider: 3-Methylethcathinone hydrochloride
  4. Meyer MR et al. - Beta-keto amphetamines metabolism studies
  5. Prosser JM, Nelson LS - The toxicology of bath salts: synthetic cathinones review

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed — this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

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24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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