3-MEC
3-MEC is a synthetic stimulant and entactogen of the substituted cathinone class. It is a research chemical with very limited documentation, as few user reports exist in the public domain. 3-MEC is generally regarded as less potent than its positional isomer 4-MEC and is considered unpopular relative to other available cathinones. As with other research chemicals in this class, it carries a risk of habit formation.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Pharmacology
Pharmacokinetics
An in-vitro metabolism study of the three methylethcathinone positional isomers tentatively identified seven metabolites for 3-MEC by liquid chromatography–high-resolution tandem mass spectrometry. The authors described this as the first report of 3-MEC metabolism.1 These are tentative structures formed in an in-vitro model; they do not establish a human metabolite profile, relative pathway contributions, bioavailability, clearance, or elimination half-life.1
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Stimulants acting on dopamine and norepinephrine systems, Other substituted cathinones
Harm Potential
Addiction & Dependence
Psychological
Classified as habit-forming.
History & Culture
3-MEC (3-Methylethcathinone) is a synthetic cathinonecitation needed that has received limited documentation in both scientific literature and user communities.
Forensic emergence
A validated liquid-chromatography tandem-mass-spectrometry method was applied to forensic serum samples collected from June 2014 through August 2016. Eight samples showed recent MMC or MEC use; after three MMC findings, the remaining five were positive for 3-MEC, while 2-MEC and 4-MEC were not
Legality
International
3-MEC is not listed by its common name, chemical names, or CAS number in the current INCB Yellow, Green, or Red Lists. It is therefore not scheduled under the 1961 Single Convention, the 1971 Convention on Psychotropic Substances, or Tables I and II of the 1988 Convention as of the cited editions; international schedules do not apply national analogue or blanket-control rules.
By Country
References
Source Pages
Citations
- Electron activated dissociation—a complementary fragmentation technique to collision-induced dissociation for metabolite identification of synthetic cathinone positional isomers. pubmed.ncbi.nlm.nih.gov (n.d.). https://doi.org/10.1016/j.aca.2023.341962123
- Separation of ortho, meta and para isomers of methylmethcathinone (MMC) and methylethcathinone (MEC) using LC-ESI-MS/MS: Application to forensic serum samples. pubmed.ncbi.nlm.nih.gov (n.d.). https://doi.org/10.1016/j.jchromb.2017.01.0461
- Decreto 560/2019, artículo 2 y Anexo I (sustituido por Decreto 122/2026); Ley 23.737, artículos 5 y 14. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/decreto-560-2019-326675/actualizacion1
- Decreto 560/2019, artículo 2 y Anexo I (sustituido por Decreto 122/2026); Ley 23.737, artículos 5 y 14. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/423520_dec122_jpg/archivo1
- Decreto 560/2019, artículo 2 y Anexo I (sustituido por Decreto 122/2026); Ley 23.737, artículos 5 y 14. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/decreto-122-2026-423520/texto1
- Decreto 560/2019, artículo 2 y Anexo I (sustituido por Decreto 122/2026); Ley 23.737, artículos 5 y 14. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/ley-23737-138/actualizacion1
- Criminal Code Act 1995, ss 301.1 and 301.9; Criminal Code Regulations 2019, Schedule 1. legislation.gov.au (n.d.). https://www.legislation.gov.au/C2004A04868/2026-06-30/2026-06-30/text/original/epub/OEBPS/document_2/document_2.html1
- Criminal Code Act 1995, ss 301.1 and 301.9; Criminal Code Regulations 2019, Schedule 1. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2019L00561/2025-03-01/2025-03-01/text/original/epub/OEBPS/document_1/document_1.html1
- Neue-Psychoaktive-Substanzen-Verordnung, Annex II, item 3, and Neue-Psychoaktive-Substanzen-Gesetz, section 4. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/geltendefassung/bundesnormen/20007642/npsv%2C%20fassung%20vom%2028.07.2021.pdf1
- Neue-Psychoaktive-Substanzen-Verordnung, Annex II, item 3, and Neue-Psychoaktive-Substanzen-Gesetz, section 4. ris.bka.gv.at (n.d.). https://ris.bka.gv.at/Dokumente/Bundesnormen/NOR40134447/NOR40134447.pdf1
Further Reading
Baumann MH et al. - 'Second-Generation' Mephedrone Analogs, 4-MEC and 4-MePPP
Cawrse BM et al. - Identifying cathinone derivatives in seized samples
ChemSpider: 3-Methylethcathinone hydrochloride
Meyer MR et al. - Beta-keto amphetamines metabolism studies
Prosser JM, Nelson LS - The toxicology of bath salts: synthetic cathinones review
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
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Recent changes7 human edits · latest
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24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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