3-Me-PCPy

This article is a stubmissing:

Dosage & Duration

Harm Potential

3-Methylrolicyclidine

M3ppy, Tolicyclidine

Psychoactive Class

Dissociative Stimulant

Chemical Class

Arylcyclohexylamine

3-Me-PCPy is an arylcyclohexylamine derivative¹ with an uncommon dual pharmacological profile, producing both dissociative and stimulant effects. Unlike most substances in its class, it combines potent NMDA antagonism with triple monoamine reuptake inhibition affecting serotonin, dopamine, and noradrenaline. It also displays high affinity for sigma receptors. This broad spectrum of activity distinguishes it from related arylcyclohexylamines, contributing to its unusual combination of stimulant and dissociative properties.

Dosage & Duration

Dosage & Duration not written up yet

Subjective Effects

3-Me-PCPy possesses an unusual pharmacological profile that combines stimulant and dissociative actions, a pairing demonstrated in animal behavioural studies. Documented human subjective reports are essentially absent, so the character of the experience in humans remains poorly characterized beyond the expectation of a mixed stimulating and dissociating effect profile.

Physical

Animal behavioural studies indicate a stimulant component alongside the compound's dissociative action; the human body load is otherwise undocumented.

Reagent Testing

Loading reagent data

Expected colorimetric results are being prepared.

Pharmacology

Pharmacodynamics

3-Me-PCPy acts as a potent NMDA receptor antagonist and a triple monoamine reuptake inhibitor, blocking the reuptake of serotonin, dopamine, and noradrenaline.² It also functions as a high-affinity sigma receptor ligand with selectivity for the σ2 subtype.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Tolerance

Cross Tolerance

Dissociatives (NMDA receptor antagonists), Other arylcyclohexylamines

Harm Potential

Harm Potential not written up yet

History & Culture

3-Me-PCPy is a synthetic arylcyclohexylamine that has emerged as a novel psychoactive substance on the research chemical market.¹ As a structural isomer of phencyclidine, it belongs to the broader family of dissociative compounds that have been systematically explored for…

Legality

By Country

AustraliaControlled (analogue)

Covered under analogue provisions as an arylcyclohexylamine derivative and structural isomer of phencyclidine. Treated as equivalent to the controlled parent compound under Australian drug law.

JapanControlled (Designated Substance)

Controlled under designated substance legislation as a generic arylcyclohexylamine derivative and structural isomer of phencyclidine. Manufacture, import, and sale are prohibited.⁴

GermanyControlled (NpSG)

Covered under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) as a generic arylcyclohexylamine derivative.³ The NpSG prohibits production and distribution but not personal possession.³

United KingdomControlled (analogue)

Covered under drug analogue laws as a generic arylcyclohexylamine derivative and structural isomer of phencyclidine. Likely controlled under the Psychoactive Substances Act 2016 which prohibits the production, supply, and importation of psychoactive substances.⁵

References

Source Pages

Citations

Suggest an edit

Spotted a mistake, an outdated claim, or something missing from the 3-Me-PCPy article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.

3-Me-PCPy

This article is a stubmissing:

Dosage & Duration

Harm Potential

3-Methylrolicyclidine

M3ppy, Tolicyclidine

Psychoactive Class

Dissociative Stimulant

Chemical Class

Arylcyclohexylamine

Dosage & Duration

Dosage & Duration not written up yet